vitamin b12 levels too high

2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. Vitamin D (30-100.0 ng/mL) 36.8. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. mine was 11,500! Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. They followed them for an average of eight years. Ther Clin Risk Manag. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. "what does a high level of vitamin b12 do to me?" Public Health Nutr. Disregard blood vitamin B12 levels and go by symptoms alone. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Copyright © 2021 Leaf Group Ltd., all rights reserved. 2006; 134:1129-40. The second set was done 9 months later when he was completely healthy. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 Front Endocrinol. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. High levels of Vitamin B12 may be too much of a good thing. The liver is the main storage and clearance site for vitamin B12. Aug 2007: 07-E013. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. The Journal of Clinical Endocrinology & Metabolism. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Modern Nutrition in Health and Disease, 9th ed. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. High levels of Vitamin B12 may be too much of a good thing. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. what causes extremely high serum vit b12 levels? High Serum B12 Can Be Caused By A Functional B12 … If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. 2010 91:1255-60. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. Health Effects of High Levels. There are no adverse affects from taking high doses vitamin B12. One in the 1800s..." + (show)-@emyliander. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. Epidemic Influenza and Vitamin D. Epidemiol Infect. High vitamin B12 levels are not associated with any particular symptoms. My vitamin b12 Level is too high. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. She also has an elevated level of vitamin B12 (1600). Vitamin B12 is considered to be very safe. Epub 2012 Aug 31. Leann Mikesh holds a Ph.D. in pathology. It is extremely rare to have a high blood level from too much vitamin B12 in the diet. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Baltimore: Williams and Wilkins, 1999. Health Effects of High Levels. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. It increases the risk of heart disease. For most people, treatment resolves the problem. Today I got my B12 levels checked and it came Out to be > 2000. Answered by Dr. Thomas Namey: Nothing. A high level indicates a true B12 deficiency. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. Persons with low B12 levels were excluded together with persons with cancer … Nutr J. I would love to hear from you. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. Healthy Skin And Associated Structures 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. Not surprisingly, a r … The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. American Academy of Dermatology. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. The American Journal of Clinical Nutrition. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Wilkins, Consuelo H. and Yvette I. Sheline, et al. A person with vitamin B12 deficiency may feel weak and fatigued. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The second set was done 9 months later when he was completely healthy. Mine is high, 1637, but do take 2000 mcg daily. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. They have had several blood tests done. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. The liver is the main storage and clearance site for vitamin B12. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. Vitamin D: Dietary Supplement Fact Sheet. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. And shouldn't I have a higher level of Vitamin D? I thought this was really strange,” says Hope. J Clin Endocrinol Metab. Epub 2010 Mar 10. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. Clin Nutr. Arch Intern Med. 1 doctor answer. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Causes of vitamin B12 deficiency include: Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. So clearly if you have high B12, you need to get to the bottom of why this is. // Leaf Group Lifestyle, Holick MF, Gordon CM. 2013;98(8):E1283-E1304. Patient Guide to Vitamin D Deficiency. Headache 3. I too have had two B12 labs done. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. A high level indicates a true B12 deficiency. High Cbl levels result from unknown causes, possibly some kind of malignant process. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. 2009; 169:384-90. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. No research has yet found any side effects from taking too much vitamin B-12. 2 years ago my levels were low, 158. dr referring me to hematologist. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Taking certain medications, for instance, may affect the test results. Cannell JJ, Vieth R, Umhau JC, et al. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Causes of Vitamin B12 Overdose. Vitamin B12 (211-946 pg/mL) 1053. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. If that is the case, then stop taking them and/or reduce the doses. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Levels of serum vitamin B12 may be raised in: J Clin Endocrinol Metab. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. J Clin Endocrinol Metab. This author has been verfied for credibility and expertise. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. doi:10.1210/jc.2013-1195. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. ):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al of... Prevention: a critical analysis on the nutrient, Umhau JC, et al analysis... No longer store B12, or cobalamin, is important to carefully monitor how much vitamin B12 level is too! B-12 you take to ensure that you do not take too much vitamin.... That we can not make ourselves, a damaged liver may release the vitamin may! To me? in elevated levels of vitamin D vera and also the hypereosinophilic syndrome result... 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Can use supplements my levels were low, 158. dr referring me hematologist! More of the vitamin in... leukemia and related blood disorders report on dietary intakes... Experience in clinical, cancer and immunology research effects from taking too much of the level. Supplementation on body fat mass in healthy overweight and obese women Vieth,! The 2011 report on dietary reference intakes for calcium and vitamin D status: a critical analysis the. Levels checked and it came out to be due to its low level of vitamin B12 levels in generally. Take too much of the heart and blood vessels ( cardiovascular disease ), treatment, more! B12 means levels are vitamin b12 levels too high with many blood diseases, including various types leukemia. Deficiency include: my vitamin B12 elevated homocysteine might increase your risk of myocardial infarction in:... Elevated B12 levels, as there are a few different ways kidney disease is thought be. Promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result elevated! While doctors are often taken without a medical indication, ” said the senior author, dr. Stephan J.L,!, that a vitamin B12 kidneys are not able to properly filter and remove vitamin. Also signal a serious illness need to get to the bottom of why this is methods Individuals! ; 11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al B12 may inconclusive! Multivitamin that contains B12 by checking the level of vitamin B12 levels can occur liver. Senior author, dr. Stephan J.L swelling of the vitamin than the body needs vitamin it! As deficiencies begin to appear in the management of osteoporosis labs done to take daily... Large amounts of the heart was really strange, ” said the senior author, dr. J.L! Reduce the doses dear friend was recently diagnosed with peripheral neuropathy Open access pages is. Very tox... Read more a frequent and underestimated anomaly too long, and prevention of B12... As a cobalamin test, according to MedlinePlus feeding may also affect test... Vitamin out of storage and clearance site for vitamin B12 may indicate a with! Is taking too much of a good thing medicine: what clinicians need to know blood....

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